Masahiro Sakagami, Ph.D.
Masahiro Sakagami, Ph.D., focuses his research on pulmonary biopharmaceutics. Despite the potential advantages of respiratory drug delivery as a route of administration, our knowledge associated with pulmonary biopharmaceutics and pharmacology is still limited. His group has developed and employed several in vivo and in vitro lung systems to characterize pulmonary disposition (absorption, metabolism and clearance) of solutes and fluid, and to assess therapeutic potential of new molecular entities for inhalation. Currently, the research is focused on corticosteroids, therapeutic macromolecular peptides, proteins and antibodies for inhalation in the treatment of asthma, emphysema and certain systemic diseases. These studies will provide valuable information on understanding pulmonary biopharmaceutics and pharmacology for inhaled therapeutics.